Enhancement by stannous chloride of calcium entry into motor nerve terminals
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چکیده
منابع مشابه
Enhancement by carbachol of transmitter release from motor nerve terminals.
In the endplates of rat phrenic nerve-diaphragm, application of the acetylcholine-like compound, carbachol, causes a marked increase in transmitter release, as measured electrophysiologically using miniature endplate potential frequency. Washing out of carbachol reverses the increase in frequency. The ability of carbachol to increase transmitter release is greatly enhanced by perfusion of the p...
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Action potentials and afterpotentials were recorded via a microelectrode inserted into motor axons innervating the lizard ceratomandibularis muscle. Intra-axonal injection of Lucifer yellow dye indicated that these axons innervate multiple (at least 6-25) motor terminals. In 10 mM tetraethylammonium (TEA), the action potential was followed by a sequence of afterpotentials, whose amplitude and d...
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We have used fura-2 fluorescence to study the effects of repetitive stimulation producing posttetanic potentiation (PTP) at crayfish neuromuscular junctions on presynaptic calcium concentration. Fura-2 was injected into the preterminal axon of the excitor motor neuron to the claw opener muscle of a walking leg. Pictures of presynaptic terminals on the muscle surface were obtained with a charge-...
متن کاملalpha-Latrotoxin releases calcium in frog motor nerve terminals.
alpha-Latrotoxin (alpha-LTX) is a neurotoxin that accelerates spontaneous exocytosis independently of extracellular Ca(2+). Although alpha-LTX increases spontaneous transmitter release at synapses, the mechanism is unknown. We tested the hypothesis that alpha-LTX causes transmitter release by mobilizing intracellular Ca(2+) in frog motor nerve terminals. Transmitter release was measured electro...
متن کاملExocytosis in peptidergic nerve terminals exhibits two calcium-sensitive phases during pulsatile calcium entry.
The link between electrical activity, Ca2+ entry through voltage-gated channels, and transmitter or hormone secretion is a central issue in neurobiology. In peptidergic nerve terminals of the mammalian neurohypophysis (NHP), secretion is elicited by patterned bursts of action potentials (APs). All parameters of the bursts are important to elicit efficient secretion, including AP frequency, AP b...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1990
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)55941-8